When muscle cells undergo anaerobic respiration, they become fatigued and painful. This is now known to be caused by Naim 15:22 AP Biology Chapter 9 When muscle cells undergo anaerobic respiration, they become fatigued and painful. This is now known to be caused by A. Buildup of pyruvate B. Buildup of lactate C. Increase in sodium ions D. Increase in potassium ions E. Increase in ethanol Learn More : Share this Share on FacebookTweet on TwitterPlus on Google+