Which structure is not involved in the breakdown of macromolecules in most animal cells? Naim 08:08 AP Biology Which structure is not involved in the breakdown of macromolecules in most animal cells? a. Phagosome b. Primary lysosome c. Secondary lysosome d. Golgi apparatus e. Ribosome Answer: e. Ribosome Learn More : Share this Share on FacebookTweet on TwitterPlus on Google+