The lock-and-key analogy for enzymes applies to the specificity of enzymes____. Naim 11:38 AP Biology Chapter 10 The lock-and-key analogy for enzymes applies to the specificity of enzymes____. a. interacting with ions b. as they form their tertiary and quaternary structure c. interacting with water d. binding to their substrate Answer: D Learn More : Share this Share on FacebookTweet on TwitterPlus on Google+