Direct-acting neurotransmitters ________. Naim 23:36 Fundamental of the Nervous System and Nervous Tissue Direct-acting neurotransmitters ________. A) require cyclic AMP B) mediate very slow responses C) open ion channels to provoke rapid responses D) act through second messengers Answer: C) open ion channels to provoke rapid responses Learn More : Share this Share on FacebookTweet on TwitterPlus on Google+