Centromeres uncouple, sister chromatids are separated, and the two new chromosomes move to opposite poles of the cell. Naim 01:54 AP Biology Practice Questions Centromeres uncouple, sister chromatids are separated, and the two new chromosomes move to opposite poles of the cell. A. telophase B. anaphase C. prometaphase D. metaphase E. prophase Answer: B Learn More : Share this Share on FacebookTweet on TwitterPlus on Google+